Effect of Itraconazole and Terbinafine on Leishmania Major Promastigotes
نویسندگان
چکیده
The antiporliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major promastigotes are reported. Treatment of promastigote cultures with itraconazole or with terbinafine induced growth arrest. Concentrations of 0.75 μ/l or more of itraconazole induced cell lysis after 72 hours. However, even relatively large concentrations of terbinafine (2.0 μ/l) did not induce cell lysis. The IC 50 for itraconazole and terbinafine were 0.31 μl/l and 3.3 μl/l respectively.
منابع مشابه
Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum.
In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.
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